A Japanese research team recently in the British natural - Communications magazine published an article called, they found that gout is not only renal excretion of uric acid due to the function to reduce the intestinal tract to reduce uric acid function is also a cause of the disease.
Gout is due to purine anabolic increased, uric acid produce too much or because of uric acid excretion bad Erzhi blood uric acid increased, and continued in the state of the hyperuricemia, gout can cause severe joint pain. To date, researchers have been simply rely on renal excretion of uric acid.
Pharmaceutical University in Tokyo and other institutions of a joint study group found that the play "pump" effect "of ABCG2 protein in the kidney, small intestine and large intestine play a role in the excretion of uric acid. The study conducted on mice, researchers in the mice kidneys discharge uric acid function is the same artificially suppress the generation "of ABCG2 protein in the intestine, reducing the function of uric acid in the intestinal tract, the result of uric acid accumulation in the mice. The researchers believe that the kidney assumed a two-thirds of the uric acid excretion, and the rest by intestinal bear.
The research team, Professor Pharmaceutical University, Tokyo City, Tin Mei pointed out, this is the first discovered of the close relationship between gout and intestinal tract, which may help to find new prevention of gout method or the development of relevant therapeutic agents.